CLASSROOM DAY
Session Slot: Monday, 11:30 - 12:25
AudioVisual Request: None
Session Organizer: Scott, David W.
Session Title: Classroom Day
1. Statistics and the Search For Disease Genes
Weir, Bruce S., North Carolina State University
Address: Department of Statistics North Carolina State University Raleigh NC 27695-8203
Phone: 919-515-3574
Fax: 919-515-7315
Email: weir@stat.ncsu.edu
Abstract: A review of current statistical methods for locating human disease genes will be given as part of the classroom day program. One of the outcomes of the human genome project has been the development of large numbers of easily-scored ``genetic markers.'' If markers at known locations on the human genome are found to have an association with disease status in a population, this may be because the disease gene is close to the marker location. It may also be a consequence of the evolutionary history of the population. Among the many statistical issues that need to be addressed is that of correcting for multiple tests when as many as 60,000 markers are examined. The variation in levels of association due to evolution must also be accommodated.Key words: Genome project, human disease, genetics
AudioVisual Request: None