A
method toward mapping of common traits
Shaw-Hwa Lo
Department of Statistics Columbia University Abstract
The
mapping of complex/common traits is an important yet difficult research
area. Many common human disorders are believed to be "complex" or
multifactorial, meaning that they cannot be attributed to alleles of a
single gene or one risk factor. Many genes and environmental factors
contribute modest effects to a combined action in deciding these
traits. Even the mutation spectrum for many simple Mendelian diseases
can be quite complex. Mapping methodologies that simultaneously inspect
disjoint loci are crucial for the success of genes mappings. We first
review an alternative method proposed in (Lo and Zheng 2002, 2004),
using family-trio data and several disease models, followed by a
demonstration of applying this method to IBD data. The outcomes of this
practice suggested the potentials of this approach in drawing
substantial joint information in dealing with high dimensional
problems. The main idea applies more generally than to special genetic
problems. If time permits, a general version will be presented- dealing
with the problem of detecting which, of many variables, have an effect
on a dependent variable. In a sense, we are addressing the problem of
locating a few needles in a haystack.
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