Some
Estimation and Hypothesis Testing Problems in Fluctuation Analysis
Xiaowei Wu Statistics Department Rice University Abstract
Fluctuation analysis is a
widely
used technique of making statistical inference on mutation rates in
cultured cells. This paper reviews some classical point and interval
estimators of mutation rate, and presents a modified median estimator,
which allows for large spread of the total culture population size
N(t). Hypothesis testing techniques are also proposed for comparing
mutation rates between different cultures.
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