Fall 1998 
Mathematical Biology Seminar
Seminars at UH meet from 2:00 to 3:00 in room 648, 
Phillip Guthrie Hoffman Building. 
Seminars at Rice meet from 2:30 to 3:30 in Duncan Hall 1044. 
Exceptions are noted in schedule below. 
Parking at UH is available in the paid parking garage underneath 
University Hilton Hotel and Hotel School, Entrance 1 off Calhoun.  
Parking tokens will be provided by the Math Department. 
Parking at Rice is available in visitor spots in Lot C (Abercrombie lot), Entrance 16 from Rice Blvd.  
-  27 January at Rice  
 William Fitzgibbon, Professor of Mathematics, University of Houston
 Singularly Perturbed Hodgkin Huxley Models
 
 
-  17 February at UH  
 Jeff Morgan
 
 
 ABSTRACT:
-  24 March at Rice  
 Olivier Lichtarge
 Evolutionary studies of protein 
sequence-structure and function
 
 
-  7 April at UH  
 Patrick King, Department of Statistics, Rice University
 Microsatellite-based statistics for inferring 
patterns of population growth
 
 ABSTRACT: Demographic change 
in populations may involve periods 
of growth, decline, or constant size.  These changes leave 
signatures on the genetic composition of the population.
Here we consider the performance of five statistics for 
inferring these population size changes using samples 
of microsatellite alleles from loci evolving under a 
stepwise mutation model.  Three statistics are 
based on the imbalance index beta, defined as the ratio of 
two estimators of the product of effective population size 
and mutation rate (Kimmel et al. 1998); 
the fourth statistic is based on the ratio of observed 
to expected allele size variance (DiRienzo et al. 1998, Reich 
et al. 1999); and the fifth is based on the observed 
kurtosis of the allele size distribution (Reich and 
Goldstein 1998).
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