Sampling distributions of alleles under models of neutral evolution
Plan
Mathematical model for sampling distributions of alleles
Genetic drift
Mutation
Infinite sites model
Statistics of mutations (segregating sites)
Number of segregating sites
Pairwise differences
Histogram of pairwise differences
Classes of mutations
Histogram of classes of mutations
Coalescence method
Coalescence – pairwise statistics
PPT Slide
Coalescence – continuous time approximations
Coalescence n-sample
Independence of metrics (coalescence times) and topology
Coalescence – statistics of pairwise differences
Coalescence – population with time varying size
Population with time-varying size
Mutation classes
Conclusions
Models versus data
Models versus data II
Models versus data III
Email: kimmel@rice.edu
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