Mutation

Mutation follows a Poisson process with intensity ? measured per locus (per site) per generation. Spatial characterization of places and effects caused, further specifies a mutation model. Most often applied are:

• infinite sites model, where it is assumed that each mutation takes place at a DNA site that never mutated before;

• infinite alleles model, where each mutation produces an allele never present in a population before;

• recurrent mutation model, where multiple changes of the nucleotide at a site are possible;

• stepwise mutation model, where mutation acts bidirectionally, increasing or reducing the number of repeats of a fixed DNA motif.

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