Journal Club Spring 2000

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• 18 February
  Alex Renwick and Chad Shaw
  
  
  
• 3 March
  Chad Shaw and Alex Renwick
  Room Change to DH 2014
  "Artificial Evolution Experiments: a critical review of Sun et al's 1996 paper"
  Abstract: Artificial evolution is an unusual area of molecular biology which presents several interesting analytical problems. Sun et al (1996) were the first to tackle the area seriously, yet their analysis has some problems. Sun's scientific description of the artificial evolution experiment is not faithful to the methods and goals of actual experiments. As a result, the modeling and analysis may be improved upon. The following issues will be the considered in tomorrow's talk:
  1) exact formulae for finite generation sampling
  2) modeling of mutation during the experiment
  3) consideration of experimetlists questions and goals such as monitoring the extent of "sequence space exploration"
  
  
• 24 March
  Krzysztof Topolski
  
  
• 14 April
  Chad Shaw
  Room Change to DH 2014
  Title: Compound Processes built using M.T. G.W. processes: statistics through genealogy
  Abstract: Multitype Galton-Watson BP can be used as a platform on which a secondary process can be superimposed. The distribution of observed characteristics on sampled individuals can then be analyzed by a dual analysis which takes account of a particle's genealogy and its exposure to the secondary process. Distributions of observable characterisitcs can be obtained by using network-type algorithims common in the study of hidden Markov Models. I will show how this analysis can be applied to molecules sampled from PCR reactions.
  
  
• 19 May
  Janet Siefert
  Room Change to DH 2014
  Title: Tempo and Mode of Molecular Evolution Using Evolved Ribozymes
  Abstract: We will discuss in vitro evolved ribozymes, reconstruction of their phylogenetic history, philosphy of doing such, tractability and practability of finding the reconstruction, and what/who is out their trying similar stunts.
  
  

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