\contentsline {chapter}{\numberline {1}Genome-wide linkage studies}{1}
\contentsline {author}{Cathryn M. Lewis}{1}
\contentsline {section}{\numberline {1.1}Introduction}{1}
\contentsline {section}{\numberline {1.2}Statistical methods for meta-analysis of linkage studies}{2}
\contentsline {section}{\numberline {1.3}Genome Search Meta-Analysis method }{2}
\contentsline {section}{\numberline {1.4}Collaborative or published information? }{6}
\contentsline {section}{\numberline {1.5}Summed ranks or average ranks?}{7}
\contentsline {section}{\numberline {1.6}Bin width}{7}
\contentsline {section}{\numberline {1.7}Weighted analysis}{7}
\contentsline {section}{\numberline {1.8}GSMA software}{9}
\contentsline {section}{\numberline {1.9}Power to detect linkage using the GSMA}{10}
\contentsline {section}{\numberline {1.10}Extensions of the GSMA }{11}
\contentsline {section}{\numberline {1.11}Limitations of the GSMA }{13}
\contentsline {subsection}{\numberline {1.11.1}File drawer problem}{13}
\contentsline {subsection}{\numberline {1.11.2}Garbage in, garbage out}{14}
\contentsline {subsection}{\numberline {1.11.3}Apples and Oranges}{14}
\contentsline {section}{\numberline {1.12}Disease studies using the GSMA}{14}
\contentsline {section}{\numberline {1.13}The Multiple Scan Probability method (MSP)}{15}
\contentsline {section}{\numberline {1.14}Conclusions}{16}
\contentsline {section}{\numberline {1.15}Acknowledgements}{17}
\contentsline {chapter}{Bibliography}{19}