Rudy Guerra







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Rudy Guerra

Department of Statistics

Rice University





University of California, Berkeley (1992), Ph.D. Statistics

University of California, Berkeley (1987), M.A. Mathematics

University of Texas, San Antonio (1984), B.S. Applied Mathematics




Rice University: Professor (2004-present)

Rice University: Associate Professor (2000-2004)

Southern Methodist University: Associate Professor (1998‑2000)

Southern Methodist University: Director, Biostatistics Center (1997-2000)

Southern Methodist University: Assistant Professor (1991‑1997)


Honors and Awards


Sigma Xi for Outstanding Scientific Research (1999)

National Research Council Postdoctoral Award (1991)

Graduate Student Outstanding Teaching Award (UC Berkeley, 1988)

National Hispanic Scholarship Fellow (1985‑86, 1989)

National Institutes of Health MARC Fellow (1985‑89)


Current Research Grants and Contracts:


1.      National Institutes of Health (NCI, 2003-2008). A training program in biostatistics for cancer research. Investigator and Co-Director [Gary Rosner (MDACC), PI]


2.      National Institutes of Health (2002-2006). Modeling lung cancer: Risks, progression, and screening. Co-investigator. (Marek Kimmel, PI, Rice University)


3.      National Science Foundation (2002-2005). Bioinformatics: From sequence to expression and structure – An innovative research-oriented course. Co-Principal Investigator. (Marek Kimmel, PI, Rice University)


4.      National Institutes of Health (2002-2009). Proteomics Technologies to Study Airway Inflammation. Co-investigator. (A. Kurosky, PI, UTMB-Galveston)





Refereed Publications


1.                  Guerra, R, MS McPeek, TP Speed, and PM Stewart (1992). A Bayesian analysis for mapping from radiation hybrid data. Cytogenetics and Cell Genetics, 59:104‑106.


2.                  Barre, DE, R Guerra, R Verstraete, Z Wang, SM Grundy, and JC Cohen (1994). Genetic analysis of a polymorphism in the human apolipoprotein A‑I promoter: Effects of plasma HDL‑cholesterol levels. Journal of Lipid Research, 35:1292‑1296.


3.                  Cohen, J.C., Z. Wang, S.M. Grundy, M. Stoesz, and R. Guerra (1994). Variation at the hepatic lipase and apolipoprotein AI/CIII/AIV loci is a major cause of genetically determined variation in plasma HDL cholesterol levels. Journal of Clinical Investigation, 94:2377‑2384.


4.                  Mooser, V., F.P. Mancini, S. Bopp, A. Petho‑Schramm, R. Guerra, H‑J Mueller, and H.H. Hobbs (1995). Sequence polymorphisms in the apo(a) gene associated with specific levels of Lp(a) in plasma. Human Molecular Genetics, 4:173‑181.


5.                  Mancini, F. P., Mooser, V., Guerra, R., Hobbs, H. (1995). Sequence microheterogeneity in apolipoprotein(a) gene repeats and the relationship to plasma Lp(a) levels. Human Molecular Genetics, 4:1535‑1542.


6.                  Guerra, R. and Speed, T.P. (1996).  Statistical issues arising in the analysis of DNA‑DNA hybridization experiments. Systematic Biology, 45: 586-595.


7.                  Ernst, M., Guerra, R., and Schucany, W. (1996). Scatterplots for unordered pairs. The American Statistician, 50:260-265.


8.                  Basu, S., Guerra, R., and Read, R., (1996) Bootstrap confidence intervals for concentration parameters in dilution assays,  Journal of Agricultural, Biological, and Environmental Statistics, 1:454-466.


9.                  McPherson, R., Guerra, R., Grundy, S., and Cohen, J. (1996). Allelic variation in the gene encoding the cholesterylester transfer protein is associated with variation in the plasma concentrations of cholesteryl ester transfer protein, Journal of Lipid Research, 37:1743-1748


10.              Wan, Y., Cohen, J., and Guerra, R. (1997). A permutation test for the robust sib pair linkage method, Annals of Human Genetics, 61:79-87.


11.              Guerra, R. , Polansky, A., and Schucany, W. (1997). Bootstrap with kernel smoothing for discrete data, Computational Statistics and Data Analysis, 26: 163-176.


12.              Guerra, R., Wang, J., Grundy, S.M., Cohen, J.C. (1997). A hepatic lipase (LIPC) allele associated with high plasma concentrations of high-density lipoprotein lipase cholesterol, Proceedings of the National Academy of Sciences, 94:4532-4537.


13.              Stoesz, M., Cohen, J.C., Mooser, V., Marcovina, S., Guerra, R. (1997). Extension of the Haseman‑Elston method to multiple alleles and multiple loci: Theory and practice for candidate genes, Annals of Human Genetics, 61: 263-274.


14.              Mooser, V., Sheer, D., Marcovina, S. Wang, J., Guerra, R., Cohen, J.C., Hobbs, H. (1997) The Apo(a) gene is the major determinant of plasma Lp(a) levels in African-Americans, American Journal of Human Genetics, 61: 402-417.


15.              Guerra, R., Zhao, B., Mooser, V., Stafforini, D., Johnston, J.M., Cohen, J.C. (1997). Determinants of plasma platelet activating factor acetylhydrolase: Heritability and relationship to plasma lipoproteins, Journal of Lipid Research, 38: 2281-2288.


16.              Wang, J., Freeman, D., Grundy, S., Levine, D., Guerra, R., Cohen, J. (1998).  Linkage between cholesterol a-hydroxylase and high plasma low-density lipoprotein cholesterol concentrations, Journal of Clinical Investigation, 101:1283-1291.& Sons, New York.


17.              Amos, C. I. and Guerra, R. (1998).  Statistics in Human Genetics (Update), in Encyclopedia of Statistical Science, Kotz, S., Banks. D., and Read, C., eds. John Wiley & Sons, New York.


18.              Wang, J., Guerra, R., and Cohen, J.C. (1998). Statistically robust approaches for sib-pair linkage analysis, Annals of Human Genetics, 62:349-359.


19.              Zinn, A.,R., Tonk, V.S., Chen, Z., Flejter, W.L., Gardner, H.A., Guerra, R., Kushner, H.,  Schwartz, S.L., Sybert, V.P., Van Dyke, D.L., Ross, J.L. (1998). ‘Evidence for a Turner  syndrome locus or loci at Xp11.2-p.22.1, American Journal of Human Genetics, 63:1757-1766.


20.              Guerra, R., Wan, Y., Jia, A., Amos, C., Cohen, J. (1999). Testing for linkage under robust genetic models, Human Heredity, 49:146-153.


21.              Goldstein, D.R., Sain, S.R., Guerra, R., Etzel, C.J. (1999). Meta-analysis by combining parameter estimates: simulated linkage, Genetic Epidemiology, (Suppl. 1):S581-585.


22.              Guerra, R., Etzel, C.J., Goldstein, D.R., Sain, S.R. (1999). Meta-analysis by combining P-values: simulated linkage studies, Genetic Epidemiology, (Suppl. 1):S605-S609.


23.              Wang, J., Guerra, R., and Cohen, J.C. (1999). A statistically robust variance components approach for quantitative trait linkage analysis, Annals of Human Genetics, 63:249-262.


24.              Fine, K.D., Do, K. Schulte, K., Ogunji, F., Guerra, R., Osowski, L., McCormak, J. (2000). High prevalence of celiac sprue-like HLA-DQ genes and enteropathy in patients with the microscopic colitis syndrome, American Journal of Gastroenterology, 95:1974-82.


25.              Guerra, R., Sain, S.R., and Carney, G. (2000). Statistical issues arising in environmental equity: A case study in Louisiana, Proceedings of the American Statistical Association, Biometrics Section.


26.              Guerra, R. (2001). Comments on Some Advice to Advisors: A Word to the Advisees, STATS, Winter.


27.              Guerra, R. (2001). The statistics of baseball rankings: Hitters, STATS, Fall.


28.              Guerra, R. (2002). Meta-analysis in human genetics studies. In Biostatistcal Genetics  and  Genetic  Epidemiology, R. Elston, J. Olson, & L. Palmer (eds), Wiley Reference in Biostatistics.


29.              Berge, K., von Bergmann, K., Lutjohann, D., Guerra, R., Grundy, S., Hobbs, H., and Cohen, J. (2002). Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8, Journal of Lipid Research, 43:486-494.


30.              Etzel, C. and Guerra, R. (2002) Meta-analysis of genetic linkage analysis of quantitative trait loci. American Journal of Human Genetics, 71:56-65.


31.              Shohet, R.V., Vega, G.L., Bersot, T.P., Mahley, R.W., Grundy, S.M., Guerra, R., Cohen, J.C. (2002). Sources of variability in genetic association studies: Insights from the analysis of hepatic lipase (LIPC), Human Mutation, 19:536-542.


32.              Han, J. and Guerra, R. (2003) Cost efficiency of genetic linkage studies using mixtures of selected sib-pairs. Science and Statistics: Festschtrift  for Terence Speed, D. Goldstein (ed.). Institute of Mathematical Statistics, Lecture Notes-Monograph Series, Volume 40.


33.              Valentine, J., Guerra, R. and Cohen, J. (2003). Family History is a Major Determinant of Subclinical Peripheral Arterial Disease in Young Adults, Journal of Vascular Surgery, in press.




Membership of Professional and Scientific Societies


American Statistical Association

American Society of Human Genetics

Society of Genetic Epidemiology

Society for the Advancement of Chicanos and Native Americans in Science



Professional Activities


Program Committee, Summer Research Conference sponsored by the Southern Regional Council on Statistics, Chair of Statistical Genetics Section, 1996.

Program Committee, the Joint Statistical Meetings, Co-chair of General Methodology Section, 1996.

Program Committee, Summer Research Conference sponsored by the Southern Regional Council on Statistics, Chair of Biostatistics Section, 1998.

Program Committee, Conference of Texas Statisticians, Dallas, 1998.

National Science Foundation, Statistics and Probability Screening Panel, 1998.

North Texas Chapter of the American Statistical Association, Secretary and Treasurer, 1998-99.

Program Committee, Society for the Advancement of Chicanos and Native Americans in Science (SACNAS), Chair of Mathematics and Statistics Section, 1999.

Program Committee, Society for the Advancement of Chicanos and Native Americans in Science (SACNAS), Scientific Symposia, 2000.

Program Committee, Conference of Texas Statisticians, San Antonio, 2001.

National Institutes of Health, Study Section SNEM-5, Member 2002-2005

Program Chair, Conference of Texas Statisticians, Houston, 2002.

Program co-Chair, Southern Regional Council of Statistics (SRCOS) Annual Meeting, Georgia, 2003


Editorial Activities


American Journal of Human Genetics

Annals of Human Genetics

Communications in Statistics

Computational Statistics & Data Analysis

European Journal of Human Genetics

Human Heredity

Journal of the American Statistical Association

Journal of Lipid Research

STATS (Associate Editor, 1999-2001)

The American Statistician


University Service


Graduate Council

Keck Center for Computational and Structural Biology, Seminar Chair (2003-2004)

Keck Center for Computational and Structural Biology, Rice University Training Director & Executive Committee (2003-2004)




Departmental Activities


Seminar Coordinator (Spring 2002; Spring 2003)

Biostatistics Program Committee (2000-present)

Fondren Library Laison (2002-present)

Undergraduate Advisor (2001-present)

Co-Director Biostatistics Training in Cancer Research Program (2003-2008)

Co-Director NSF VIGRE PFUG in Bioinformatics




Ph.D. Students


  1. Prabir Majumder (1995, SMU), “Variance components for genetics models.”
  2. Ying Wan (1996, SMU), “Significance testing for the robust sib-pair linkage method.”
  3. Jinping Wang (1996, SMU), “Experimental design and statistical analysis in serial dilution assays,” (Co-advisor with S. Basu)


  1. Jo Kuo, (1999, SMU), “Mapping quantitative trait loci: Sampling considerations using bivariate data.”
  2. Carol Etzel (1999, SMU), “Meta-analysis for genetic linkage studies.”
  3. Jian Han, (2001, SMU), “Bivariate linkage analysis using score tests.”
  4. Zhaoxia Yu (current, Rice), statistical genetics.
  5. Blair Christian (current, Rice), bioinformatics.
  6. Garrett Reed Fox (current, Rice)
  7. Jason Andrew Gershman (current, Rice)
  8. Josue’ C. Noyola-Martinez (current, Rice)



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   Rudy Guerra 2003